STXBP5 and STX4

Data Source:
HPRD (in vitro)

		STXBP5	STX4
Description		syntaxin binding protein 5	syntaxin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Acetylcholine-gated Channel Complex Synaptic Vesicle SNARE Complex Neuromuscular Junction Extrinsic Component Of Neuronal Dense Core Vesicle Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Extrinsic Component Of Presynaptic Membrane Presynaptic Cytosol	Storage Vacuole Extracellular Space Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Endomembrane System Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Syntaxin-1 Binding Syntaxin Binding Myosin II Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Exocytosis Regulation Of Synaptic Vesicle Priming Protein Transport Regulation Of Exocytosis Positive Regulation Of GTPase Activity Positive Regulation Of Exocytosis Regulation Of Protein Secretion Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis	Positive Regulation Of Immunoglobulin Production Intracellular Protein Transport Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Positive Regulation Of Cell Population Proliferation Regulation Of Exocytosis Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Cellular Response To Interferon-gamma Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways			Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bronchopulmonary dysplasia ( 23897914) Factor VIII levels ( 30586737) Low vWF levels ( 26486471) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma plasminogen activator levels ( 24578379) Systolic blood pressure ( 30224653) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) White blood cell count ( 32888494)	Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)
Interacting Genes		3 interacting genes: SNAP23 STX1A STX4	72 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 EMD FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP29 SNAP47 STX10 STX11 STX12 STX16 STX1A STX1B STX2 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM199 TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B ZFPL1
Entrez ID		134957	6810
HPRD ID		06845	01722
Ensembl ID		ENSG00000164506	ENSG00000103496
Uniprot IDs		Q5T5C0	B7Z425 Q12846
PDB IDs
Enriched GO Terms of Interacting Partners?
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