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TMEM42 and EDA
Data Source:
BioGRID
(two hybrid)
TMEM42
EDA
Description
transmembrane protein 42
ectodysplasin A
Image
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Membrane
Extracellular Region
Collagen Trimer
Extracellular Space
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Membrane
Intracellular Membrane-bounded Organelle
Apical Part Of Cell
Molecular Function
Protein Binding
Signaling Receptor Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Death Receptor Agonist Activity
Receptor Ligand Activity
Biological Process
Immune Response
Cell-matrix Adhesion
Gene Expression
Positive Regulation Of Gene Expression
Cell Differentiation
Tumor Necrosis Factor-mediated Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pigmentation
Animal Organ Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Salivary Gland Cavitation
Hair Follicle Placode Formation
Trachea Gland Development
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
TNFs bind their physiological receptors
Drugs
Diseases
Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
Tooth agenesis; Hypodontia
GWAS
Acne (severe) (
24927181
)
Bipolar disorder (
31043756
)
Male-pattern baldness (
30573740
)
Metabolite levels (
23823483
)
Monobrow (
27182965
)
Primary tooth development (number of teeth) (
23704328
20195514
)
Primary tooth development (time to first tooth eruption) (
23704328
20195514
)
Tooth agenesis (maxillary lateral incisors) (
29364747
)
Interacting Genes
54 interacting genes:
AQP3
AQP6
BDKRB1
CD79A
DTX2
EBP
EDA
ELOVL4
ERGIC3
FAM174A
FAM209A
GET1
GJA8
GOLM2
GPR152
GPX8
HSD17B11
HSD17B13
LEPROTL1
LHFPL5
LMNA
MFF
MGAT5B
MMD
MMGT1
MRM1
MTIF3
NEMP1
PROP1
PSCA
RABAC1
RBPMS
REEP1
REEP2
RETREG3
RHBDD1
SAR1A
SCN3B
SEC11C
SERINC2
SHISAL1
SLC18A1
SLC34A2
SMIM14
SVOPL
TLX3
TM4SF19
TMEM147
TMEM14B
TMEM237
TMEM35A
TMEM74
VENTX
ZDHHC15
24 interacting genes:
ATP6V0C
CTXN3
CYB561
DOLK
EDA2R
EDAR
EMP1
EMP3
FURIN
GIMAP5
LEPROTL1
LPAR3
MAL
MS4A13
NIPAL3
OSTC
OSTCP1
PLN
PMP22
SEC22A
SLC38A7
TMEM42
TMEM50B
TMEM60
Entrez ID
131616
1896
HPRD ID
15540
02347
Ensembl ID
ENSG00000169964
ENSG00000158813
Uniprot IDs
Q69YG0
A0A0U5J797
Q92838
PDB IDs
1RJ7
1RJ8
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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