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EDA and ATP6V0C
Data Source:
BioGRID
(two hybrid)
EDA
ATP6V0C
Description
ectodysplasin A
ATPase H+ transporting V0 subunit c
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Extracellular Space
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Membrane
Intracellular Membrane-bounded Organelle
Apical Part Of Cell
Lysosomal Membrane
Plasma Membrane
Focal Adhesion
Endosome Membrane
Integral Component Of Membrane
Phagocytic Vesicle Membrane
Proton-transporting V-type ATPase, V0 Domain
Azurophil Granule Membrane
Extracellular Exosome
Tertiary Granule Membrane
Ficolin-1-rich Granule Membrane
Molecular Function
Signaling Receptor Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Death Receptor Agonist Activity
Receptor Ligand Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Proton-transporting ATP Synthase Activity, Rotational Mechanism
Proton-transporting ATPase Activity, Rotational Mechanism
Biological Process
Immune Response
Cell-matrix Adhesion
Gene Expression
Positive Regulation Of Gene Expression
Cell Differentiation
Tumor Necrosis Factor-mediated Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pigmentation
Animal Organ Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Salivary Gland Cavitation
Hair Follicle Placode Formation
Trachea Gland Development
Positive Regulation Of Canonical Wnt Signaling Pathway
Insulin Receptor Signaling Pathway
ATP Synthesis Coupled Proton Transport
Viral Process
Regulation Of Macroautophagy
Positive Regulation Of Wnt Signaling Pathway
Transferrin Transport
Ion Transmembrane Transport
Neutrophil Degranulation
Phagosome Acidification
Proton Transmembrane Transport
Pathways
TNFs bind their physiological receptors
ROS and RNS production in phagocytes
Neutrophil degranulation
Insulin receptor recycling
Transferrin endocytosis and recycling
Amino acids regulate mTORC1
Ion channel transport
Drugs
Tiludronic acid
Diseases
Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
Tooth agenesis; Hypodontia
GWAS
Male-pattern baldness (
30573740
)
Metabolite levels (
23823483
)
Monobrow (
27182965
)
Primary tooth development (number of teeth) (
23704328
20195514
)
Primary tooth development (time to first tooth eruption) (
23704328
20195514
)
Tooth agenesis (maxillary lateral incisors) (
29364747
)
Interacting Genes
24 interacting genes:
ATP6V0C
CTXN3
CYB561
DOLK
EDA2R
EDAR
EMP1
EMP3
FURIN
GIMAP5
LEPROTL1
LPAR3
MAL
MS4A13
NIPAL3
OSTC
OSTCP1
PLN
PMP22
SEC22A
SLC38A7
TMEM42
TMEM50B
TMEM60
53 interacting genes:
AQP6
ARF6
ASGR2
CD53
CD69
CD79A
CERS2
CLEC14A
CLEC17A
CLEC2D
CLIC1
CPLX4
CREB3
DNAJC1
DRD2
EDA
EDA2R
ERBB2
ERH
EVI2A
FAM210B
FFAR2
GPR152
GPR25
GPR42
HSD17B13
HTR2C
KLRC1
LMNA
LRRC25
MARK3
MCEMP1
MDFI
MSR1
NIPAL3
OPRM1
PDCD1LG2
PI16
PSMA3
RETREG3
SCN3B
SLC35E3
SLC7A1
SMIM3
SPACA1
SSMEM1
STOM
SUSD3
TMEM139
TMEM31
TMEM9
VSIR
ZCCHC12
Entrez ID
1896
527
HPRD ID
02347
00162
Ensembl ID
ENSG00000158813
ENSG00000185883
Uniprot IDs
A0A0U5J797
Q92838
P27449
PDB IDs
1RJ7
1RJ8
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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