EDA and TMEM50B

Data Source:
BioGRID (two hybrid)

		EDA	TMEM50B
Description		ectodysplasin A	transmembrane protein 50B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Receptor Ligand Activity	Molecular_function Protein Binding
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Animal Organ Development Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway	Biological_process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)	Crohn's disease ( 23128233) Educational attainment ( 25201988)
Interacting Genes		24 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 NIPAL3 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60	21 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35C2 TMEM14B TMEM52B TMEM88 TMX2
Entrez ID		1896	757
HPRD ID		02347	10747
Ensembl ID		ENSG00000158813	ENSG00000142188
Uniprot IDs		A0A0U5J797 Q92838	P56557
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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