EDA and SLC38A7

Data Source:
BioGRID (two hybrid)

		EDA	SLC38A7
Description		ectodysplasin A	solute carrier family 38 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Integral Component Of Membrane Axon Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Receptor Ligand Activity	L-histidine Transmembrane Transporter Activity L-glutamate Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-methionine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Animal Organ Development Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway	Amino Acid Transmembrane Transport Sodium Ion Transport Asparagine Transport Glutamine Transport Branched-chain Amino Acid Transport L-alanine Transport L-glutamate Transmembrane Transport Methionine Transport L-serine Transport L-aspartate Transmembrane Transport L-histidine Transmembrane Transport
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer ( 30648747) QT interval ( 19305408) Schizophrenia ( 25056061 29483656)
Interacting Genes		24 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 NIPAL3 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60	52 interacting genes: ACBD5 AMIGO1 APH1A AQP2 AQP9 ARL13B BTNL9 CLCN7 CLDN7 CLEC10A CPLX4 CREB3L3 CYB561 CYB5R3 EDA ERGIC3 ERP29 EVI2B FAM209A FCER1G FKBP7 GJA8 GJB5 GPR152 GPR42 IL10RA KIR2DL3 LMNA LY6G6C LYVE1 MMGT1 MUC1 ODF4 OPRM1 PANX1 PDCD1LG2 RNF5 SCN3B SERP2 SHISAL1 SLC10A1 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SPINT1 SSMEM1 SYPL2 TMEM237 TMEM52B TSPAN8 YIPF6
Entrez ID		1896	55238
HPRD ID		02347	07701
Ensembl ID		ENSG00000158813	ENSG00000103042
Uniprot IDs		A0A0U5J797 Q92838	H3BMC5 Q9NVC3
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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