COMT and CREB3L1

Data Source:
BioGRID (two hybrid)

		COMT	CREB3L1
Description		catechol-O-methyltransferase	cAMP responsive element binding protein 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Intracellular Membrane-bounded Organelle Extracellular Exosome	Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Methylation Developmental Process Neurotransmitter Catabolic Process Dopamine Metabolic Process Catecholamine Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS	CREB3 factors activate genes
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)
Interacting Genes		68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2	194 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C4orf3 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MFSD5 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35C2 SLC39A2 SLC39A9 SLC52A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1
Entrez ID		1312	90993
HPRD ID		00284	16751
Ensembl ID		ENSG00000093010	ENSG00000157613
Uniprot IDs		A0A140VJG8 P21964	B2RA75 Q96BA8
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?
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