COMT and ACE

Data Source:
HPRD (in vivo)

		COMT	ACE
Description		catechol-O-methyltransferase	angiotensin I converting enzyme
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity	Endopeptidase Activity Carboxypeptidase Activity Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding Metallodipeptidase Activity
	Biological Process	Methylation Developmental Process Neurotransmitter Catabolic Process Dopamine Metabolic Process Catecholamine Catabolic Process	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Systemic Arterial Blood Pressure Proteolysis Spermatogenesis Regulation Of Blood Pressure Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Mononuclear Cell Proliferation Hormone Catabolic Process Peptide Catabolic Process Amyloid-beta Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Blood Vessel Diameter Maintenance Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS	Metabolism of Angiotensinogen to Angiotensins
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril Epicaptopril N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril Cilazaprilat
Diseases			Renal tubular dysgenesis Allograft rejection
GWAS		Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 24162737 30820047) Angiotensin-converting enzyme activity ( 20066004) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 30072576) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 28135244 27841878 28739976) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 21886157) Metabolite levels ( 23281178) Serum metabolite levels ( 24625756 23093944) Systolic blood pressure ( 27841878 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30297969)
Interacting Genes		68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2	4 interacting genes: AGTR2 BDKRB2 COMT CSNK2A1
Entrez ID		1312	1636
HPRD ID		00284	00108
Ensembl ID		ENSG00000093010	ENSG00000159640
Uniprot IDs		A0A140VJG8 P21964	B4DKH4 P12821
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D	1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P 4C2Q 4C2R 4CA5 4CA6 4UFA 4UFB 5AM8 5AM9 5AMA 5AMB 5AMC 6EN5 6EN6 6F9R 6F9T 6F9U 6F9V 6H5W 6H5X 6QS1 6TT1 6TT3 6TT4 6ZPQ 6ZPT 6ZPU
Enriched GO Terms of Interacting Partners?
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