EDARADD and RNF111

Data Source:
BioGRID (two hybrid)

		EDARADD	RNF111
Description		EDAR associated death domain	ring finger protein 111
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Multicellular Organism Development Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair
Pathways		TNFs bind their physiological receptors	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)	Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)
Interacting Genes		11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I	54 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PML PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W VAPB
Entrez ID		128178	54778
HPRD ID		05965	09318
Ensembl ID		ENSG00000186197	ENSG00000157450
Uniprot IDs		Q8WWZ3	A0A024R5T5 Q6ZNA4
PDB IDs			2KIZ 5LG0 5LG7
Enriched GO Terms of Interacting Partners?
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