EDARADD and SHPRH

		EDARADD	SHPRH
Description		EDAR associated death domain	SNF2 histone linker PHD RING helicase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleosome Nucleoplasm
	Molecular Function	Protein Binding	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Multicellular Organism Development Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Protein Polyubiquitination DNA Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Protein Ubiquitination
Pathways		TNFs bind their physiological receptors	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I	10 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG
Entrez ID		128178	257218
HPRD ID		05965	10476
Ensembl ID		ENSG00000186197	ENSG00000146414
Uniprot IDs		Q8WWZ3	B3KX98 Q149N8
PDB IDs			2M85 4QN1
Enriched GO Terms of Interacting Partners?
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