GJB4 and TMBIM6

Data Source:
BioGRID (two hybrid)

		GJB4	TMBIM6
Description		gap junction protein beta 4	transmembrane BAX inhibitor motif containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Integral Component Of Plasma Membrane Connexin Complex Cell Junction	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity
	Biological Process	Cell-cell Signaling Sensory Perception Of Smell Olfactory Behavior Transmembrane Transport Gap Junction-mediated Intercellular Transport	Negative Regulation Of Immunoglobulin Production Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Negative Regulation Of Apoptotic Process Negative Regulation Of Endoribonuclease Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Gap junction assembly
Drugs
Diseases		Erythrokeratodermia variabilis
GWAS		Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	General cognitive ability ( 29844566)
Interacting Genes		9 interacting genes: C4orf3 COMT KLRC1 LHFPL5 TM4SF4 TMBIM6 TMEM11 TMEM218 TMEM86A	68 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MFSD14B MMGT1 MS4A3 ODF4 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 RNF185 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A
Entrez ID		127534	7009
HPRD ID		05666	02851
Ensembl ID		ENSG00000189433	ENSG00000139644
Uniprot IDs		A0A654IBS8 Q9NTQ9	A0A024R0Z5 P55061
PDB IDs
Enriched GO Terms of Interacting Partners?
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