GJB4 and TMEM218

Data Source:
BioGRID (two hybrid)

		GJB4	TMEM218
Description		gap junction protein beta 4	transmembrane protein 218
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Integral Component Of Plasma Membrane Connexin Complex Cell Junction	Cilium Integral Component Of Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Protein Binding
	Biological Process	Cell-cell Signaling Sensory Perception Of Smell Olfactory Behavior Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Gap junction assembly
Drugs
Diseases		Erythrokeratodermia variabilis
GWAS		Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		9 interacting genes: C4orf3 COMT KLRC1 LHFPL5 TM4SF4 TMBIM6 TMEM11 TMEM218 TMEM86A	72 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		127534	219854
HPRD ID		05666	19054
Ensembl ID		ENSG00000189433	ENSG00000150433
Uniprot IDs		A0A654IBS8 Q9NTQ9	A2RU14
PDB IDs
Enriched GO Terms of Interacting Partners?
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