TRAF2 and TRAF1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vivo)

		TRAF2	TRAF1
Description		TNF receptor associated factor 2	TNF receptor associated factor 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex Plasma Membrane Signaling Receptor Complex IRE1-TRAF2-ASK1 Complex	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Plasma Membrane Signaling Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein-macromolecule Adaptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Cellular Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Death-inducing Signaling Complex Assembly Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Protein K63-linked Ubiquitination Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Pulse pressure ( 30578418) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24782177 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) White blood cell count ( 32888494)
Interacting Genes		378 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AGR2 AIMP2 AKR1B15 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARHGEF6 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 AXIN1 BAHD1 BANP BAZ2B BCL10 BCL6 BECN1 BEX2 BEX3 BIRC2 BIRC3 BOD1L2 BYSL C22orf15 C2CD6 CALCOCO2 CAPN15 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC187 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC37 CDC42 CDCA3 CDK18 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHCHD2 CHMP2B CHUK CREB5 CRY1 CRY2 CRYBA2 CTCF CWF19L2 CYB5R2 CYLD DDI1 DDX6 DGCR6 DLGAP5 DMTN DTNB DVL2 DVL3 EAF1 EBF2 EDAR EDARADD EEF1AKNMT EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 EP400 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM124B FAM161A FAM161B FAM214B FAM50B FAM90A1 FAM9A FARS2 FATE1 FBF1 FBXO28 FDXACB1 FLNA FLYWCH1 FNDC11 FNDC3B FOXN1 FXR2 GABPB1 GAS8 GCA GCKR GEM GORASP2 GPANK1 GPKOW GRIPAP1 GSE1 GSG1 GSTP1 GSTZ1 HENMT1 HINFP HIVEP3 HOXA1 HOXB5 HSPA12B IKBKB IL15RA IMPDH2 INO80B IP6K3 IPO11 IQUB IRF4 ITPK1 ITPRIPL1 JUN KANK2 KANSL1 KIAA0408 KIAA1217 KIF26B KIFC3 KLF3 LENG1 LINC02875 LNX1 LNX2 LONRF1 LRRK2 LTBR LYSMD1 LZTS2 MACROH2A1 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MBLAC1 MFAP1 MISP MKRN3 MORN3 MOS MPP3 MSRB2 MVP MYO15B NAB2 NATD1 NCAPH2 NEBL NECAP2 NEDD9 NEK6 NFIL3 NFKBID NGFR NHSL2 NIF3L1 NMUR2 NOXA1 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PALS1 PCGF2 PCGF5 PDLIM7 PDZD4 PEG3 PGBD1 PIAS2 PIBF1 PIN1 PKN1 POLR3C POM121 PPL PPP1R18 PPP1R32 PRKAB2 PRKRIP1 PRPF18 PSMB1 PSMD9 PSME3IP1 PSMF1 QARS1 QRICH1 RAD23A RAD54L2 RALBP1 RANBP3 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIN1 RIPK1 RIPK2 RIPK3 RIPPLY1 RIPPLY3 RNF146 RNF4 RRAS2 RSPH14 SAMD11 SCNM1 SETD5 SH2D4A SHC3 SIAH2 SMG9 SMURF2 SNAI1 SNRNP25 SOX13 SOX30 SOX5 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCAF1 TCEA2 TCEANC TCL1A TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TIGD4 TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM14 TRIM31 TRIM37 TRIM42 TRIM50 TROAP TRPC4AP TRPT1 TSGA10IP TSHZ2 TSHZ3 TSSC4 TTC23 TXN UBC UBE2D1 UBE2D2 UBE2I UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 UTP14C UTP23 VEZF1 VWA2 WASF1 YES1 ZBTB16 ZBTB24 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZKSCAN3 ZMAT2 ZMYM5 ZNF205 ZNF250 ZNF35 ZNF410 ZNF417 ZNF438 ZNF488 ZNF544 ZNF572 ZNF574 ZNF646 ZNF648 ZNF655 ZNF662 ZNF688 ZNF774 ZSCAN23 ZSCAN32 ZSWIM3 ZZZ3	245 interacting genes: A1CF ABHD17A ACTN3 AKAP17A AQP1 ARID5A ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf109 C1orf216 C2CD6 C4orf45 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCDC198 CCHCR1 CD40 CDCA3 CDK18 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRACR2A CRY2 CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 DUSP13 DUSP21 DUSP4 EBF2 EDAR EHHADH ENKD1 EWSR1 FAM161A FAM161B FAM86C1P FBF1 FBXL18 FOSL2 GADD45GIP1 GATA1 GATA2 GATAD2B GCA GCM2 GEM GFI1B GIT2 GLIS3 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HELT HEY2 HGS HIVEP3 HMG20B HNRNPM HOXA1 HOXB5 HOXC8 HOXD12 IKBKB JOSD1 KANK2 KIAA1217 KIF1A KLHL38 KPNA2 KRT3 KRT75 LATS1 LCOR LIN37 LMNTD2 LNX1 LNX2 LRRN1 LTBR MACIR MAP3K14 MAP6 MAPRE2 MATR3 METTL17 MORN3 MOS MSGN1 MYEF2 MYOZ1 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PATZ1 PBX3 PDE4D PHF21A PIN1 PITX1 PITX2 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PPP1R32 PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RCOR3 RIIAD1 RIPK1 RIPK2 RIPOR3 RIPPLY1 RNF31 RTP5 SAMD11 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHC3 SHFL SIK3 SLC25A48 SLC25A6 SNRNP25 SNW1 SOHLH1 SPATA46 SPG21 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TBC1D8 TBX18 TCEA2 TCF7L2 TCL1A TEAD4 TFAP2D TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSHZ2 TSSC4 USP2 USP7 UTP14C VEZF1 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZIC1 ZNF124 ZNF20 ZNF23 ZNF250 ZNF417 ZNF440 ZNF490 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF627 ZNF648 ZNF662 ZNF669 ZNF688 ZNF697 ZNF844
Entrez ID		7186	7185
HPRD ID		03538	03418
Ensembl ID		ENSG00000127191	ENSG00000056558
Uniprot IDs		A0A024R8H5 Q12933	Q13077
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	3M0D 5E1T 5H10
Enriched GO Terms of Interacting Partners?
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