TRAF2 and BAZ2B

Data Source:
BioGRID (two hybrid)

		TRAF2	BAZ2B
Description		TNF receptor associated factor 2	bromodomain adjacent to zinc finger domain 2B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex Plasma Membrane Signaling Receptor Complex IRE1-TRAF2-ASK1 Complex	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein-macromolecule Adaptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Cellular Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Death-inducing Signaling Complex Assembly Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)	Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Sudden cardiac arrest ( 21738491) Tourette syndrome ( 30818990)
Interacting Genes		378 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AGR2 AIMP2 AKR1B15 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARHGEF6 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 AXIN1 BAHD1 BANP BAZ2B BCL10 BCL6 BECN1 BEX2 BEX3 BIRC2 BIRC3 BOD1L2 BYSL C22orf15 C2CD6 CALCOCO2 CAPN15 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC187 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC37 CDC42 CDCA3 CDK18 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHCHD2 CHMP2B CHUK CREB5 CRY1 CRY2 CRYBA2 CTCF CWF19L2 CYB5R2 CYLD DDI1 DDX6 DGCR6 DLGAP5 DMTN DTNB DVL2 DVL3 EAF1 EBF2 EDAR EDARADD EEF1AKNMT EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 EP400 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM124B FAM161A FAM161B FAM214B FAM50B FAM90A1 FAM9A FARS2 FATE1 FBF1 FBXO28 FDXACB1 FLNA FLYWCH1 FNDC11 FNDC3B FOXN1 FXR2 GABPB1 GAS8 GCA GCKR GEM GORASP2 GPANK1 GPKOW GRIPAP1 GSE1 GSG1 GSTP1 GSTZ1 HENMT1 HINFP HIVEP3 HOXA1 HOXB5 HSPA12B IKBKB IL15RA IMPDH2 INO80B IP6K3 IPO11 IQUB IRF4 ITPK1 ITPRIPL1 JUN KANK2 KANSL1 KIAA0408 KIAA1217 KIF26B KIFC3 KLF3 LENG1 LINC02875 LNX1 LNX2 LONRF1 LRRK2 LTBR LYSMD1 LZTS2 MACROH2A1 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MBLAC1 MFAP1 MISP MKRN3 MORN3 MOS MPP3 MSRB2 MVP MYO15B NAB2 NATD1 NCAPH2 NEBL NECAP2 NEDD9 NEK6 NFIL3 NFKBID NGFR NHSL2 NIF3L1 NMUR2 NOXA1 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PALS1 PCGF2 PCGF5 PDLIM7 PDZD4 PEG3 PGBD1 PIAS2 PIBF1 PIN1 PKN1 POLR3C POM121 PPL PPP1R18 PPP1R32 PRKAB2 PRKRIP1 PRPF18 PSMB1 PSMD9 PSME3IP1 PSMF1 QARS1 QRICH1 RAD23A RAD54L2 RALBP1 RANBP3 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIN1 RIPK1 RIPK2 RIPK3 RIPPLY1 RIPPLY3 RNF146 RNF4 RRAS2 RSPH14 SAMD11 SCNM1 SETD5 SH2D4A SHC3 SIAH2 SMG9 SMURF2 SNAI1 SNRNP25 SOX13 SOX30 SOX5 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCAF1 TCEA2 TCEANC TCL1A TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TIGD4 TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM14 TRIM31 TRIM37 TRIM42 TRIM50 TROAP TRPC4AP TRPT1 TSGA10IP TSHZ2 TSHZ3 TSSC4 TTC23 TXN UBC UBE2D1 UBE2D2 UBE2I UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 UTP14C UTP23 VEZF1 VWA2 WASF1 YES1 ZBTB16 ZBTB24 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZKSCAN3 ZMAT2 ZMYM5 ZNF205 ZNF250 ZNF35 ZNF410 ZNF417 ZNF438 ZNF488 ZNF544 ZNF572 ZNF574 ZNF646 ZNF648 ZNF655 ZNF662 ZNF688 ZNF774 ZSCAN23 ZSCAN32 ZSWIM3 ZZZ3	17 interacting genes: APIP BIVM CEP70 CTBP2 FXR2 GOLGA2 HMBOX1 HSF2BP PRNP RASGEF1B SEPTIN2 STAC3 TFIP11 TRAF2 TRIM23 ZBTB14 ZBTB8A
Entrez ID		7186	29994
HPRD ID		03538	09295
Ensembl ID		ENSG00000127191	ENSG00000123636
Uniprot IDs		A0A024R8H5 Q12933	Q9UIF8
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	2E7O 3G0L 3Q2F 4CUP 4CUQ 4CUR 4CUS 4CUT 4CUU 4IR3 4IR4 4IR5 4IR6 4NR9 4NRA 4NRB 4NRC 4QC1 4QC3 4QF3 4RVR 4XUA 4XUB 5CQ3 5CQ4 5CQ5 5CQ6 5CQ7 5CQ8 5CQA 5CU8 5CUA 5CUB 5CUC 5CUD 5CUE 5CUG 5DYU 5DYX 5E73 5E74 5E9I 5E9K 5E9L 5E9M 5E9Y 5L8T 5L8U 5L96 5L97 5L98 5L99 5MGE 5MGF 5MGG 5OR9 5ORB 5PB7 5PB8 5PB9 5PBA 5PBB 5PBC 5PBD 5PBE 5PBF 5PBG 5PBH 5PBI 5PBJ 5PBK 5PBL 5PBM 5PBN 5PBO 5PBP 5PBQ 5PBR 5PBS 5PBT 5PBU 5PBV 5PBW 5PBX 5PBY 5PBZ 5PC0 5PC1 5PC2 5PC3 5PC4 5PC5 5PC6 5PC7 5PC8 5PC9 5PCA 5PCB 5PCC 5PCD 5PCE 5PCF 5PCG 5PCH 5PCI 5PCJ 5PCK 5PCL 5PCM 5PCN 5PCO 5PCP 5PCQ 5PCR 5PCS 5PCT 5PCU 5PCV 5PCW 5PCX 5PCZ 5PD0 5PD1 5PD2 5PD3 5PD4 5PD5 5PD6 5PD7 5PD8 5PD9 5PDA 5PDB 5PDC 5PDD 5PDE 5PDF 5PDG 5PDH 5PDI 5PDJ 5PDK 5PDL 5PDM 5PDN 5PDO 5PDP 5PDQ 5PDR 5PDS 5PDT 5PDU 5PDV 5PDW 5PDX 5PDY 5PDZ 5PE0 5PE1 5PE2 5PE3 5PE4 5PE5 5PE6 5PE7 5PE8 5PE9 5PEA 5PEB 5PEC 5PED 5PEE 5PEF 5PEG 5PEH 5PEI 5PEJ 5PEK 5PEL 5PEM 5PEN 5PEO 5PEQ 5PER 5PES 5PET 5PEU 5PEV 5PEW 5PEX 5PEY 5PEZ 5PF0 5PF1 5PF2 5PF3 5PF4 5PF5 5PF6 5PF7 5PF8 5PF9 5PFA 5PFB 5PFC 5PFD 5PFE 5PFF 5PFG 5PFH 5PFI 5PFJ 5PFL 5PFM 5PFN 5PFO 5PFP 5PFQ 5PFR 5PFS 5PFT 5PFU 5PFV 5PFW 5PFX 5PFY 5PFZ 5PG0 5PG1 5PG2 5PG3 5PG4 5PG5 5PG6 5PG7 5PG8 5PG9 5PGA 5PGB 5PGC 5PGD 5PGE 5PGF 5PGG 5PGH 5PGI 5PGJ 5PGK 5PGL 5PGN 5PGO 5PGP 5PGQ 5PGR 5PGS 5PGT 6FGT 6FGU 6FH6 6FH7 6FHQ 6FI1
Enriched GO Terms of Interacting Partners?
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