AGAP2 and GRIP1

Data Source:
BioGRID (pull down)

		AGAP2	GRIP1
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	glutamate receptor interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Dendrite Cytoplasmic Vesicle Neuron Projection Perikaryon Membrane Raft Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding	Protein Binding Beta-catenin Binding Protein C-terminus Binding Signaling Receptor Complex Adaptor Activity Glucocorticoid Receptor Binding
	Biological Process	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Activation Of Protein Kinase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity	Dendrite Development Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Positive Regulation Of Neuron Projection Arborization
Pathways		Netrin-1 signaling	Trafficking of GluR2-containing AMPA receptors
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		13 interacting genes: AKT1 ARF1 CDC42 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 RAC1 RAC2 RHOA	42 interacting genes: AGAP2 AR CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		116986	23426
HPRD ID		05687	19086
Ensembl ID		ENSG00000135439	ENSG00000155974
Uniprot IDs		A0A024RB55 F8VVT9 Q99490	Q9Y3R0
PDB IDs		2BMJ 2IWR 2RLO	2JIL
Enriched GO Terms of Interacting Partners?
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