AGAP2 and HOMER1

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		AGAP2	HOMER1
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	homer scaffold protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Z Disc Axon Dendrite Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Ion Channel Binding
	Biological Process	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Activation Of Protein Kinase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Postsynaptic Neurotransmitter Receptor Activity Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity
Pathways		Netrin-1 signaling	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)	Bipolar disorder ( 31043756) Blood and toenail selenium levels ( 25343990) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)
Interacting Genes		13 interacting genes: AKT1 ARF1 CDC42 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 RAC1 RAC2 RHOA	34 interacting genes: ABI1 ABI3 AGAP2 AIMP1 BRME1 C1orf116 CENPQ DBNL DNM3 EFNB2 FAM9A FAT1 FCHSD2 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 NUP54 PATJ PIAS2 RAD54L2 RASAL3 RYR1 RYR2 SHANK1 SHANK2 STX12 SYCE2 TANC1 TRAF5 TRPC1 ZMYM5
Entrez ID		116986	9456
HPRD ID		05687	09211
Ensembl ID		ENSG00000135439	ENSG00000152413
Uniprot IDs		A0A024RB55 F8VVT9 Q99490	Q5U5K4 Q86YM7
PDB IDs		2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?
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