CNTROB and LYST

Data Source:
HPRD (two hybrid)

		CNTROB	LYST
Description		centrobin, centriole duplication and spindle assembly protein	lysosomal trafficking regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding Protein Kinase Binding
	Biological Process	Centriole Replication Centrosome Separation Regulation Of Cilium Assembly Mitotic Cytokinetic Process	Phagocytosis Lysosome Organization Protein Localization Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus
Pathways
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Refractive error ( 32231278)	Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 26502338 19838195)
Interacting Genes		17 interacting genes: APTX COASY CWF19L2 DAPK1 DUSP29 ELOA EPM2AIP1 LYST MCRS1 PELI1 PNKP RAD23A RSPH14 SYT6 TCEA2 TSHZ2 TTC23	24 interacting genes: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521
Entrez ID		116840	1130
HPRD ID		13991	06060
Ensembl ID		ENSG00000170037	ENSG00000143669
Uniprot IDs		Q8N137	Q99698
PDB IDs
Enriched GO Terms of Interacting Partners?
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