WDFY2 and SYP

Data Source:
BioGRID (two hybrid)

		WDFY2	SYP
Description		WD repeat and FYVE domain containing 2	synaptophysin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Early Endosome Vesicle Intracellular Membrane-bounded Organelle	Synaptic Vesicle Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Cholesterol Binding Syntaxin-1 Binding SH2 Domain Binding Identical Protein Binding Protein Self-association
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Fat Cell Differentiation	Endocytosis Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Membrane Organization Cellular Response To Organic Substance Regulation Of Synaptic Vesicle Exocytosis Regulation Of Opioid Receptor Signaling Pathway
Pathways
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325)
Interacting Genes		5 interacting genes: ARL6IP1 MTDH RPRM SYP YIF1A	41 interacting genes: AP1G1 ARFIP2 CAND2 CD160 DIABLO FARS2 GAB1 GDNF GRB2 HSFX1 HSFX2 JOSD2 LNPK MIEF1 MIEF2 MRM1 MRRF MTERF3 MYG1 NDRG4 PBX3 PITPNC1 PLIN3 PNKP PPIF PTCD1 PTPN9 RBFA SH3GLB1 SIAH1 SIAH2 SMG9 SNX1 SPG21 SSX5 STARD4 THAP4 TUFM VAMP2 WDFY2 WIPI2
Entrez ID		115825	6855
HPRD ID		18294	02435
Ensembl ID		ENSG00000139668	ENSG00000102003
Uniprot IDs		Q96P53	P08247
PDB IDs
Enriched GO Terms of Interacting Partners?
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