CHRNA4 and RHOU

Data Source:
BioGRID (pull down)

		CHRNA4	RHOU
Description		cholinergic receptor nicotinic alpha 4 subunit	ras homolog family member U
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane	Golgi Membrane Podosome Cytosol Plasma Membrane Focal Adhesion Cell Projection
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding	GTPase Activity Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Sensory Perception Of Pain Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential	Endocytosis Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Cytokine-mediated Signaling Pathway Cell Projection Assembly Cdc42 Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling
Drugs		Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 28972577 26440539) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking status (heavy vs never) ( 26423011)	Aging ( 22773346) Basal cell carcinoma ( 24403052 25855136 27539887 18849993) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH	128 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 ARNTL AS3MT ATP5MG ATP6AP1 BDNF BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A ESYT1 FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 MARCKS ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIV2L SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		1137	58480
HPRD ID		00333	06965
Ensembl ID		ENSG00000101204	ENSG00000116574
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q59FV0	A0A024R3Q7 Q7L0Q8
PDB IDs		2GVT 2LLY 5KXI 6CNJ 6CNK 6UR8 6USF	2Q3H
Enriched GO Terms of Interacting Partners?
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