CHRNA4 and CHRNB4

Data Source:
HPRD (in vitro)

		CHRNA4	CHRNB4
Description		cholinergic receptor nicotinic alpha 4 subunit	cholinergic receptor nicotinic beta 4 subunit
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein-containing Complex Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Sensory Perception Of Pain Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation
Drugs		Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate	Nicotine Butabarbital Fluoxetine Dextromethorphan Ethanol Pentolinium Levacetylmethadol Epibatidine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 28972577 26440539) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking status (heavy vs never) ( 26423011)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 32469254 33020668) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)
Interacting Genes		8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH	6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 MEOX2 UBQLN1
Entrez ID		1137	1143
HPRD ID		00333	00337
Ensembl ID		ENSG00000101204	ENSG00000117971
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q59FV0	P30926
PDB IDs		2GVT 2LLY 5KXI 6CNJ 6CNK 6UR8 6USF	2ASG 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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