SERPINA3 and ABCC5

Data Source:
BioGRID (two hybrid)

		SERPINA3	ABCC5
Description		serpin family A member 3	ATP binding cassette subfamily C member 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	ATP Binding Organic Anion Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATPase Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation	Purine Nucleotide Transport Hyaluronan Biosynthetic Process Glutathione Transmembrane Transport Xenobiotic Transport Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier
Pathways		Platelet degranulation Neutrophil degranulation	Hyaluronan biosynthesis and export ABC-family proteins mediated transport
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Curcumin Curcumin sulfate
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)	Anterior chamber depth ( 24603532) Basophil percentage of white cells ( 32888494) Eosinophil counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	4 interacting genes: AK2 RBP5 SERPINA3 SMC2
Entrez ID		12	10057
HPRD ID		00120	06898
Ensembl ID		ENSG00000196136	ENSG00000114770
Uniprot IDs		A0A024R6P0 P01011	O15440
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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