VPS45 and BCAR3

Data Source:
BioGRID (two hybrid)

		VPS45	BCAR3
Description		vacuolar protein sorting 45 homolog	BCAR3 adaptor protein, NSP family member
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cellular_component Golgi Apparatus Endosome Membrane Integral Component Of Membrane	Cytoplasm Focal Adhesion Membrane
	Molecular Function	Molecular_function Protein Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Blood Coagulation Vesicle-mediated Transport	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway
Pathways		Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)	Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		11 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNTG1 STX16 VPS11 VPS18	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		11311	8412
HPRD ID		10301	05268
Ensembl ID		ENSG00000136631	ENSG00000137936
Uniprot IDs		A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs			3T6A
Enriched GO Terms of Interacting Partners?
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