MED8 and MED25

Data Source:
HPRD (in vivo)

		MED8	MED25
Description		mediator complex subunit 8	mediator complex subunit 25
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Core Mediator Complex	Nucleoplasm Transcription Regulator Complex Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		32 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		112950	81857
HPRD ID		06991	14380
Ensembl ID		ENSG00000159479	ENSG00000104973
Uniprot IDs		Q96G25	Q71SY5
PDB IDs			2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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