MED8 and MED27

Data Source:
HPRD (in vitro)

		MED8	MED27
Description		mediator complex subunit 8	mediator complex subunit 27
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Gout (normal type) ( 32238385) Triglyceride levels ( 32203549)
Interacting Genes		32 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	11 interacting genes: AFP ARFGAP1 ESR1 FBXO7 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5
Entrez ID		112950	9442
HPRD ID		06991	05438
Ensembl ID		ENSG00000159479	ENSG00000160563
Uniprot IDs		Q96G25	A0A024R8B7 Q6P2C8
PDB IDs
Enriched GO Terms of Interacting Partners?
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