Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
POU6F2 and PKN1
Data Source:
BioGRID
(two hybrid)
POU6F2
PKN1
Description
POU class 6 homeobox 2
protein kinase N1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Biological Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Ganglion Mother Cell Fate Determination
Central Nervous System Development
Visual Perception
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Attention deficit hyperactivity disorder (inattention symptoms) (
32595297
)
Feeling hurt (
29500382
)
Glaucoma (multi-trait analysis) (
31959993
)
Hand grip strength (
29691431
)
Intraocular pressure (
29785010
31959993
30054594
)
Motion sickness (
25628336
)
Refractive error (
32231278
)
Tea consumption (
31046077
)
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
143 interacting genes:
ACTN3
ANKRD10
ARHGEF6
ASB13
BANP
BFSP2
BHLHE40
C1orf109
C5
CCHCR1
CCNC
CCNK
CDC23
CDC37
CDKN2C
CHAF1A
CIB3
CINP
CSNK2A1
CSTF2
CTNNA3
DDX6
DTNB
DYDC1
EBF1
EIF3F
EIF4EBP1
EPHB6
FHL2
FNDC3B
FOSB
GCM2
GLIS2
GMEB2
GOLGA6L9
HGS
HIVEP1
HNF1B
HOXC5
HOXC8
HSPA4
IGFN1
IMPDH2
IQUB
IRX4
ISX
KDF1
KIF5B
KLHL11
KPNA5
KPNA6
KRTAP8-1
L3MBTL2
LARP4
LMNB2
LMO3
LNX1
LONRF1
MAGEA12
MAPK9
MEIS2
MIEN1
MLLT10
MORF4L2
MSRB3
MSX2
MYL7
MYO15B
NEUROG3
NFYC
NKX3-2
NME7
NUP62CL
OAZ3
OIP5
OPLAH
OPTN
PADI4
PARVG
PDE6H
PIBF1
PKN1
PM20D2
POLR3C
POU2F1
PPIL1
PPIP5K2
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QRICH1
RAD23B
RBM39
RBPMS
RELA
SIX1
SMAD5
SMYD1
SORL1
SOX10
SSUH2
STAC
STRA8
TBX6
TCEA2
TENT5B
THADA
THAP1
TLX2
TLX3
TNPO2
TNXB
TP53BP1
TRIM73
TRIML2
TSC1
TSEN15
TTC19
TTC23
UBAC1
UFSP1
VAX2
VENTX
VEZF1
VPS9D1
XPOT
ZBTB24
ZBTB4
ZFHX2
ZFHX3
ZFP1
ZFP91
ZIM2
ZMYND12
ZNF148
ZNF319
ZNF34
ZNF384
ZNF410
ZNF574
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
Entrez ID
11281
5585
HPRD ID
10162
03019
Ensembl ID
ENSG00000106536
ENSG00000123143
Uniprot IDs
P78424
Q16512
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?