POU6F2 and SIX1

Data Source:
BioGRID (two hybrid)

		POU6F2	SIX1
Description		POU class 6 homeobox 2	SIX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Ganglion Mother Cell Fate Determination Central Nervous System Development Visual Perception	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Apoptotic Process Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Drugs
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 31959993 30054594) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 22419738 29891935 22570617) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Optic disc size ( 31809533) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946 25241763)
Interacting Genes		143 interacting genes: ACTN3 ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C1orf109 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574	15 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 H2AP MDFI PLEKHG4 POU6F2 REL TLE1 TLE3 TLE5 VTN
Entrez ID		11281	6495
HPRD ID		10162	03125
Ensembl ID		ENSG00000106536	ENSG00000126778
Uniprot IDs		P78424	Q15475
PDB IDs			4EGC
Enriched GO Terms of Interacting Partners?
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