KLHL2 and FRAS1

Data Source:
BioGRID (biochemical)

		KLHL2	FRAS1
Description		kelch like family member 2	Fraser extracellular matrix complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Basement Membrane Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Extracellular Matrix Structural Constituent Metal Ion Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Protein Transport Embryonic Limb Morphogenesis Skin Development Roof Of Mouth Development
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Fraser syndrome
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Blond vs. brown/black hair color ( 30531825) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)
Interacting Genes		31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		11275	80144
HPRD ID		09311	06382
Ensembl ID		ENSG00000109466	ENSG00000138759
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q86XX4
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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