SEC63 and SEC61B

Data Source:
HPRD (in vitro)

		SEC63	SEC61B
Description		SEC63 homolog, protein translocation regulator	SEC61 translocon subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Sec62/Sec63 Complex	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	RNA Binding Protein Binding Protein Transmembrane Transporter Activity Signaling Receptor Activity	RNA Binding Protein Binding Epidermal Growth Factor Binding
	Biological Process	Liver Development Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Nitrogen Compound Metabolic Process Multicellular Organism Aging Posttranslational Protein Targeting To Membrane, Translocation	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity
Pathways			ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Polycystic liver disease
GWAS		Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893)	Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		4 interacting genes: HSPA5 MEOX2 SEC61B SEC62	19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A
Entrez ID		11231	10952
HPRD ID		09783	06715
Ensembl ID		ENSG00000025796	ENSG00000106803
Uniprot IDs		A0A0S2Z5M1 Q9UGP8	P60468
PDB IDs			6W6L
Enriched GO Terms of Interacting Partners?
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