SUPT16H and CCT6A

Data Source:
BioGRID (two hybrid)

		SUPT16H	CCT6A
Description		SPT16 homolog, facilitates chromatin remodeling subunit	chaperonin containing TCP1 subunit 6A
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GO Annotations	Cellular Component	Nucleoplasm FACT Complex	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding
	Biological Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization Regulation Of Signal Transduction By P53 Class Mediator	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31015462) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Systolic blood pressure ( 30224653)
Interacting Genes		13 interacting genes: CCT6A GTF2E2 H2AC13 H2AX H3-3A MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2 SSRP1 SUMO2	15 interacting genes: DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN
Entrez ID		11198	908
HPRD ID		16088	00089
Ensembl ID		ENSG00000092201	ENSG00000146731
Uniprot IDs		Q9Y5B9	A0A024RDL1 P40227
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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