SUPT16H and SSRP1

Data Source:
BioGRID (pull down, proximity labelling technology)

		SUPT16H	SSRP1
Description		SPT16 homolog, facilitates chromatin remodeling subunit	structure specific recognition protein 1
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GO Annotations	Cellular Component	Nucleoplasm FACT Complex	Nucleoplasm Nucleolus FACT Complex
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding
	Biological Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication DNA Repair Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Chromatin Organization
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		13 interacting genes: CCT6A GTF2E2 H2AC13 H2AX H3-3A MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2 SSRP1 SUMO2	22 interacting genes: AURKA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AC20 H2AX H2BC21 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 SUPT16H UBE2I
Entrez ID		11198	6749
HPRD ID		16088	05061
Ensembl ID		ENSG00000092201	ENSG00000149136
Uniprot IDs		Q9Y5B9	A0A024R4Z6 Q08945
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL	4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL
Enriched GO Terms of Interacting Partners?
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