CCT6A and IMPA2

Data Source:
BioGRID (two hybrid)

		CCT6A	IMPA2
Description		chaperonin containing TCP1 subunit 6A	inositol monophosphatase 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding	Protein Binding Inositol Monophosphate 1-phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity
	Biological Process	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Synthesis of IP2, IP, and Ins in the cytosol
Drugs			Lithium cation Lithium citrate Lithium succinate Lithium carbonate
Diseases
GWAS		Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31015462) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Systolic blood pressure ( 30224653)	Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Hemoglobin ( 32888494) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Stroke ( 17434096)
Interacting Genes		15 interacting genes: DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN	6 interacting genes: CCT6A HERPUD1 IMPA1 SLC44A3 TNFRSF14 UBA3
Entrez ID		908	3613
HPRD ID		00089	09329
Ensembl ID		ENSG00000146731	ENSG00000141401
Uniprot IDs		A0A024RDL1 P40227	O14732
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8	2CZH 2CZI 2CZK 2DDK 2FVZ
Enriched GO Terms of Interacting Partners?
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