SUPT16H and MCM3

Data Source:
HPRD (in vivo)

		SUPT16H	MCM3
Description		SPT16 homolog, facilitates chromatin remodeling subunit	minichromosome maintenance complex component 3
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GO Annotations	Cellular Component	Nucleoplasm FACT Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding
	Biological Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization Regulation Of Signal Transduction By P53 Class Mediator	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		13 interacting genes: CCT6A GTF2E2 H2AC13 H2AX H3-3A MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2 SSRP1 SUMO2	36 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ
Entrez ID		11198	4172
HPRD ID		16088	04072
Ensembl ID		ENSG00000092201	ENSG00000112118
Uniprot IDs		Q9Y5B9	A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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