KAT7 and KCTD13

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KAT7	KCTD13
Description		lysine acetyltransferase 7	potassium channel tetramerization domain containing 13
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Histone H3-K14 Acetyltransferase Complex Site Of DNA Damage	Nucleoplasm Nuclear Body Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	DNA Replication Origin Binding Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Natural Killer Cell Differentiation DNA Replication DNA Repair Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Regulation Of DNA-dependent DNA Replication Initiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of DNA-templated Transcription, Elongation Histone H3 Acetylation Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Sorbitol Response To Hydroxyurea Response To Actinomycin D Response To Dithiothreitol Response To Anisomycin Positive Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Nucleotide-excision Repair	Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Synaptic Transmission Protein Homooligomerization Neural Precursor Cell Proliferation
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean reticulocyte volume ( 32888494)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Hand grip strength ( 29691431) Menarche (age at onset) ( 25231870) Schizophrenia ( 28991256 25056061 29483656 30285260) Urinary sodium excretion ( 31409800)
Interacting Genes		44 interacting genes: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP126 CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN H2AC20 H3C1 H4C1 HAP1 HOOK2 ING4 KATNBL1 KCTD13 LRIF1 MAP2K1 MCM2 MCRS1 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPTIN5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165	21 interacting genes: ADRB2 ARMC7 CDC37 CRK CUL3 EXOSC5 GORASP2 KAT7 KCTD10 LNX1 NTAQ1 NUDT18 PCNA POLD2 POLR1C PPARG PSMA1 RHOA TNFAIP1 VTA1 ZMYND19
Entrez ID		11143	253980
HPRD ID		07135	12339
Ensembl ID		ENSG00000136504	ENSG00000174943
Uniprot IDs		O95251	A0A3B3IS45 Q8WZ19
PDB IDs		5GK9 6MAJ 6MAK	4UIJ
Enriched GO Terms of Interacting Partners?
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