KAT7 and ORC2

Data Source:
BioGRID (enzymatic study)

		KAT7	ORC2
Description		lysine acetyltransferase 7	origin recognition complex subunit 2
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Histone H3-K14 Acetyltransferase Complex Site Of DNA Damage	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	DNA Replication Origin Binding Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	Natural Killer Cell Differentiation DNA Replication DNA Repair Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Regulation Of DNA-dependent DNA Replication Initiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of DNA-templated Transcription, Elongation Histone H3 Acetylation Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Sorbitol Response To Hydroxyurea Response To Actinomycin D Response To Dithiothreitol Response To Anisomycin Positive Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Nucleotide-excision Repair	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways		HATs acetylate histones	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean reticulocyte volume ( 32888494)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		44 interacting genes: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP126 CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN H2AC20 H3C1 H4C1 HAP1 HOOK2 ING4 KATNBL1 KCTD13 LRIF1 MAP2K1 MCM2 MCRS1 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPTIN5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165	28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5
Entrez ID		11143	4999
HPRD ID		07135	03112
Ensembl ID		ENSG00000136504	ENSG00000115942
Uniprot IDs		O95251	A0A024R411 Q13416
PDB IDs		5GK9 6MAJ 6MAK	5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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