DCAF1 and PYGO2

Data Source:
BioGRID (pull down)

		DCAF1	PYGO2
Description		DDB1 and CUL4 associated factor 1	pygopus family PHD finger 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Beta-catenin-TCF Complex
	Molecular Function	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)	Chromatin Binding Protein Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Asthma ( 32296059)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2	7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP
Entrez ID		9730	90780
HPRD ID		11674	06065
Ensembl ID		ENSG00000145041	ENSG00000163348
Uniprot IDs		Q9Y4B6	Q5T170 Q9BRQ0
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45	2XB1 4UP0 4UP5
Enriched GO Terms of Interacting Partners?
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