DCAF1 and CCP110

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		DCAF1	CCP110
Description		DDB1 and CUL4 associated factor 1	centriolar coiled-coil protein 110
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	Centrosome Centriole Cytosol Cilium Protein-containing Complex
	Molecular Function	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Ciliary Basal Body Organization Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Centrosome Duplication Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Cilium Assembly Negative Regulation Of Centriole Elongation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2
Drugs
Diseases
GWAS		Asthma ( 32296059)
Interacting Genes		19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2	13 interacting genes: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 DCAF1 PCNT PNMA1 TFIP11 USP33
Entrez ID		9730	9738
HPRD ID		11674	10848
Ensembl ID		ENSG00000145041	ENSG00000103540
Uniprot IDs		Q9Y4B6	O43303
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?