RNF7 and APOBEC3G

Data Source:
BioGRID (enzymatic study)

		RNF7	APOBEC3G
Description		ring finger protein 7	apolipoprotein B mRNA editing enzyme catalytic subunit 3G
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex	P-body Nucleus Cytoplasm Cytosol Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex
	Molecular Function	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Deoxycytidine Deaminase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation Response To Redox State	Positive Regulation Of Defense Response To Virus By Host Cytidine Deamination Negative Regulation Of Transposition Viral Process Base Conversion Or Substitution Editing Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination DNA Demethylation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233)
Interacting Genes		43 interacting genes: APOBEC3F APOBEC3G ASB11 BTRC CASP7 CBFB CDC34 CHFR CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS ELOB ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 UBE2S	7 interacting genes: APOBEC3F APP ARIH2 HDAC6 PRKACA PTN RNF7
Entrez ID		9616	60489
HPRD ID		04840	06172
Ensembl ID		ENSG00000114125	ENSG00000239713
Uniprot IDs		Q9UBF6	Q9HC16
PDB IDs		2ECL	2JYW 2KBO 2KEM 3E1U 3IQS 3IR2 3V4J 3V4K 4ROV 4ROW 5ZVA 5ZVB 6BUX 6BWY 6K3J 6K3K
Enriched GO Terms of Interacting Partners?
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