TLK2 and FEZ1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TLK2	FEZ1
Description		tousled like kinase 2	fasciculation and elongation protein zeta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549) Lifespan ( 25918517)	Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)
Interacting Genes		17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		11011	9638
HPRD ID		10527	09212
Ensembl ID		ENSG00000146872	ENSG00000149557
Uniprot IDs		B4DUC2 J3QLK5 Q86UE8	Q99689
PDB IDs		5O0Y
Enriched GO Terms of Interacting Partners?
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