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BAD and RPS6KA2
Data Source:
HPRD
(in vitro, in vivo)
BAD
RPS6KA2
Description
BCL2 associated agonist of cell death
ribosomal protein S6 kinase A2
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Phospholipid Binding
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Kinase Binding
Protein Phosphatase Binding
Protein Phosphatase 2B Binding
Protein Kinase B Binding
14-3-3 Protein Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Release Of Cytochrome C From Mitochondria
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Glucose Catabolic Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Spermatogenesis
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Glucose
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Suppression By Virus Of Host Apoptotic Process
Cytokine-mediated Signaling Pathway
Cerebral Cortex Development
Positive Regulation Of Insulin Secretion
Response To Estradiol
Response To Progesterone
Positive Regulation Of Glucokinase Activity
Response To Testosterone
Response To Oleic Acid
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Drug
Response To Hydrogen Peroxide
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Type B Pancreatic Cell Proliferation
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Positive Regulation Of Epithelial Cell Proliferation
Response To Glucocorticoid
Response To Calcium Ion
Positive Regulation Of Apoptotic Process By Virus
Cellular Response To Chromate
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Response To Benzene
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Granulosa Cell Apoptotic Process
Positive Regulation Of Type B Pancreatic Cell Development
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Pathways
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Navitoclax
Diseases
GWAS
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Alzheimer's disease progression score (
29860282
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Blood pressure (smoking interaction) (
25189868
)
Dental caries (
23259602
)
Inflammatory bowel disease (
27569725
23128233
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Smooth-surface caries (
24556642
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Waist circumference (
28552196
)
Interacting Genes
45 interacting genes:
ACTN2
AKT1
ARAF
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
12 interacting genes:
BAD
CREB1
FLNC
FOS
JUN
L1CAM
MAGI1
MAP2K1
MAPK1
MAPK3
SHANK1
TP53
Entrez ID
572
6196
HPRD ID
04409
03403
Ensembl ID
ENSG00000002330
ENSG00000071242
Uniprot IDs
A0A024R562
Q92934
B7Z3B5
Q15349
X5D337
PDB IDs
1G5J
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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