FGR and DOK1

Data Source:
HPRD (in vitro)

		FGR	DOK1
Description		FGR proto-oncogene, Src family tyrosine kinase	docking protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Aggresome Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Secretory Granule Lumen Extracellular Exosome	Nucleus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Neutrophil Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Axon Guidance Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways		FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs		Dasatinib Fostamatinib Zanubrutinib
Diseases
GWAS		Body mass index ( 28892062) Systolic blood pressure ( 30224653)	Height ( 31562340)
Interacting Genes		30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ	41 interacting genes: ABL1 ABL2 BCR CRK CRKL CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		2268	1796
HPRD ID		01288	04228
Ensembl ID		ENSG00000000938	ENSG00000115325
Uniprot IDs		P09769 P78453	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs			2V76
Enriched GO Terms of Interacting Partners?
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