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GNB5 and GNG2
Data Source:
HPRD
(two hybrid)
GNB5
GNG2
Description
G protein subunit beta 5
G protein subunit gamma 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Heterotrimeric G-protein Complex
Presynapse
GTPase Activator Complex
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
G-protein Beta/gamma-subunit Complex
Extracellular Exosome
Molecular Function
GTPase Activity
GTPase Activator Activity
Protein Binding
G-protein Gamma-subunit Binding
Chaperone Binding
Protein Binding
G-protein Beta-subunit Binding
Biological Process
Protein Folding
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Dopamine Receptor Signaling Pathway
Positive Regulation Of GTPase Activity
Negative Regulation Of Voltage-gated Calcium Channel Activity
Protein Folding
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Platelet Activation
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Catecholamine Stimulus
Pathways
Activation of G protein gated Potassium channels
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Halothane
Diseases
GWAS
Lewy body disease (
25188341
)
Chronic obstructive pulmonary disease (
25584925
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Craniofacial microsomia (
26853712
)
High density lipoprotein cholesterol levels (
29403010
)
Lung cancer (smoking interaction) (
24658283
)
Non-melanoma skin cancer (
23548203
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Triglyceride levels (
31170924
)
Triglyceride levels x loop diuretics use interaction (
31806883
)
Interacting Genes
27 interacting genes:
ANXA7
APP
BNIP3L
CDKN1A
CSNK2B
DRD2
E2F2
EIF3J
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNGT1
MCM2
MVD
NR6A1
OLFM2
PSD
PSMD4
RGS11
RGS6
RGS7
RGS9
RPA1
TSC22D1
17 interacting genes:
ADCY2
ADRA2A
ADRB2
AVPR2
BTK
CACNA1H
CHRM2
GNAI1
GNB1
GNB3
GNB4
GNB5
MRGPRX1
PGGT1B
PLEKHG2
SMURF2
TBXA2R
Entrez ID
10681
54331
HPRD ID
09191
16234
Ensembl ID
ENSG00000069966
ENSG00000186469
Uniprot IDs
A0A024R5R9
A0A024R5V3
O14775
P59768
PDB IDs
4KFM
5HE0
5HE1
5HE2
5HE3
5UKK
5UKL
5UKM
5UZ7
6B3J
6CRK
6D9H
6DDE
6DDF
6E3Y
6EG8
6G79
6GDG
6K41
6K42
6KPF
6KPG
6LFM
6LFO
6LI3
6LMK
6LML
6M1H
6M1I
6M8S
6N4B
6NI3
6NIY
6OIJ
6OIK
6OMM
6ORV
6OS9
6OSA
6OT0
6P9X
6P9Y
6PB0
6PB1
6PT0
6UUN
6UUS
6UVA
6VCB
6VMS
6VN7
6WHA
6WHC
6WI9
6WPW
6WWZ
6WZG
6X18
6X19
6X1A
6XBJ
6XBK
6XBL
6XBM
7C2E
7CFM
7CFN
7K7L
7K7Z
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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