GNG2 and CHRM2

Data Source:
HPRD (in vivo)

		GNG2	CHRM2
Description		G protein subunit gamma 2	cholinergic receptor muscarinic 2
Image
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Clathrin-coated Vesicle Membrane Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding G-protein Beta-subunit Binding	G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Arrestin Family Protein Binding
	Biological Process	Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Platelet Activation Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Membrane Organization G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Halothane	Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine Rapacuronium ALKS 27 Pizotifen Fesoterodine Hexocyclium Dimetindene Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Chronic obstructive pulmonary disease ( 25584925) Cognitive decline rate in late mild cognitive impairment ( 26252872) Craniofacial microsomia ( 26853712) High density lipoprotein cholesterol levels ( 29403010) Lung cancer (smoking interaction) ( 24658283) Non-melanoma skin cancer ( 23548203) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 31170924) Triglyceride levels x loop diuretics use interaction ( 31806883)	Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PR interval ( 32439900) Pulse pressure ( 30224653) Resting heart rate ( 29769521 27798624)
Interacting Genes		17 interacting genes: ADCY2 ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNAI1 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	18 interacting genes: GJC2 GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 HERPUD1 MDH1 RGS7 SAG SET SHISA4 SLC52A2 TMEM8B TSPAN33 TSPAN7
Entrez ID		54331	1129
HPRD ID		16234	00328
Ensembl ID		ENSG00000186469	ENSG00000181072
Uniprot IDs		P59768	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs		4KFM 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6K41 6K42 6KPF 6KPG 6LFM 6LFO 6LI3 6LMK 6LML 6M1H 6M1I 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OMM 6ORV 6OS9 6OSA 6OT0 6P9X 6P9Y 6PB0 6PB1 6PT0 6UUN 6UUS 6UVA 6VCB 6VMS 6VN7 6WHA 6WHC 6WI9 6WPW 6WWZ 6WZG 6X18 6X19 6X1A 6XBJ 6XBK 6XBL 6XBM 7C2E 7CFM 7CFN 7K7L 7K7Z	1LUB 3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK 6U1N
Enriched GO Terms of Interacting Partners?
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