GNB5 and MVD

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNB5	MVD
Description		G protein subunit beta 5	mevalonate diphosphate decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Presynapse GTPase Activator Complex	Peroxisome Cytosol
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding	Diphosphomevalonate Decarboxylase Activity ATP Binding Hsp70 Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Folding Signal Transduction G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity	Dolichyl Diphosphate Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Cell Population Proliferation Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process
Pathways		Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) Synthesis of Dolichyl-phosphate
Drugs
Diseases
GWAS		Lewy body disease ( 25188341)	Feeling fed-up ( 29500382) Hair color ( 26926045)
Interacting Genes		27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	5 interacting genes: BTAF1 EEF1G EIF4EBP1 GNB5 HSPA9
Entrez ID		10681	4597
HPRD ID		09191	04454
Ensembl ID		ENSG00000069966	ENSG00000167508
Uniprot IDs		A0A024R5R9 A0A024R5V3 O14775	P53602
PDB IDs			3D4J
Enriched GO Terms of Interacting Partners?
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