CES1 and SAR1A

Data Source:
BioGRID (two hybrid)

		CES1	SAR1A
Description		carboxylesterase 1	secretion associated Ras related GTPase 1A
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lipid Droplet Cytosol	Golgi Membrane COPII Vesicle Coat Endoplasmic Reticulum Exit Site
	Molecular Function	Sterol Esterase Activity Triglyceride Lipase Activity Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity Methyl Indole-3-acetate Esterase Activity	GTPase Activity Protein Binding GTP Binding
	Biological Process	Angiotensin Maturation Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Lipid Catabolic Process Epithelial Cell Differentiation Cholesterol Homeostasis Reverse Cholesterol Transport Medium-chain Fatty Acid Metabolic Process Regulation Of Bile Acid Biosynthetic Process Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Bile Acid Secretion	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Membrane Organization Positive Regulation Of Protein Exit From Endoplasmic Reticulum COPII-coated Vesicle Cargo Loading
Pathways		Metabolism of Angiotensinogen to Angiotensins Phase I - Functionalization of compounds
Drugs		Tacrine Meperidine Levocarnitine Dextropropoxyphene Cocaine Naloxone Diamorphine Probucol Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester Cholic Acid 4-Piperidino-Piperidine N-acetyl-alpha-neuraminic acid Thenoyltrifluoroacetone Cyclandelate Avasimibe (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
Diseases
GWAS		Response to dabigatran etexilate treatment ( 23467860)
Interacting Genes		10 interacting genes: BMPR2 CREB3 CYSRT1 GORAB GUSB KPRP PDZK1IP1 PLSCR4 SAR1A VENTX	69 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 C14orf180 C3orf52 CD53 CD81 CES1 CLDN19 CLDND2 CLEC7A CMTM5 COL4A5 CTSA CXCL16 EMP3 ERG28 FAM3C GJB2 GOLT1B GRM2 GYPA HMOX2 JAGN1 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM ORMDL1 PLLP PLN PLP2 RHOT2 RMDN2 SEC22A SERP1 SLC35A1 SMIM1 SNAP47 STX7 STX8 TMEM107 TMEM109 TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5
Entrez ID		1066	56681
HPRD ID		00268	07608
Ensembl ID		ENSG00000198848	ENSG00000079332
Uniprot IDs		P23141	Q5SQT9 Q9NR31
PDB IDs		1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 5A7F 5A7G 5A7H	2GAO
Enriched GO Terms of Interacting Partners?
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