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SNCA and SMURF2
Data Source:
BioGRID
(enzymatic study)
SNCA
SMURF2
Description
synuclein alpha
SMAD specific E3 ubiquitin protein ligase 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Cell Cortex
Actin Cytoskeleton
Membrane
Inclusion Body
Axon
Growth Cone
Platelet Alpha Granule Membrane
Protein-containing Complex
Neuronal Cell Body
Axon Terminus
Perinuclear Region Of Cytoplasm
Supramolecular Fiber
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Speck
Membrane Raft
Molecular Function
SNARE Binding
Magnesium Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Actin Binding
Protein Kinase Inhibitor Activity
Fatty Acid Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Ferrous Iron Binding
Zinc Ion Binding
Oxidoreductase Activity
Kinesin Binding
Hsp70 Protein Binding
Histone Binding
Identical Protein Binding
Alpha-tubulin Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Tau Protein Binding
Phosphoprotein Binding
Phospholipase D Inhibitor Activity
Dynein Complex Binding
Cuprous Ion Binding
Ubiquitin-protein Transferase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Receptor Recycling
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Chemical Synaptic Transmission
Response To Iron(II) Ion
Regulation Of Phospholipase Activity
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Dopamine Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Priming
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Microtubule Polymerization
Receptor Internalization
Protein Destabilization
Response To Magnesium Ion
Negative Regulation Of Transporter Activity
Response To Lipopolysaccharide
Negative Regulation Of Monooxygenase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Interferon-gamma
Cellular Response To Oxidative Stress
Negative Regulation Of Histone Acetylation
SNARE Complex Assembly
Positive Regulation Of SNARE Complex Assembly
Dopamine Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Metabolic Process
Positive Regulation Of Endocytosis
Negative Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Synaptic Vesicle Endocytosis
Positive Regulation Of Inflammatory Response
Synapse Organization
Protein Tetramerization
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Regulation Of Norepinephrine Uptake
Negative Regulation Of Norepinephrine Uptake
Calcium Ion Homeostasis
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Response To Interleukin-1
Cellular Response To Copper Ion
Cellular Response To Epinephrine Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Supramolecular Fiber Organization
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Glutathione Peroxidase Activity
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Regulation Of Synaptic Vesicle Recycling
Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Presynapse Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Trophoblast Cell Migration
Pathways
Amyloid fiber formation
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Asymmetric localization of PCP proteins
Degradation of AXIN
Hedgehog 'on' state
Hedgehog 'on' state
Ub-specific processing proteases
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Resveratrol
Copper
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Blood protein levels (
30072576
29875488
)
Dementia with Lewy bodies (
29263008
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Feeling nervous (
29500382
)
Neurociticism (
29500382
)
Parkinson's disease (
22451204
20711177
21084426
21292315
19915575
19915576
25064009
32201043
31660654
27182965
28892059
22438815
28011712
20070850
21044948
24511991
21738487
32310270
)
Parkinson's disease (age of onset) (
31660654
30957308
)
Parkinson's disease in GBA mutation carriers (
31755958
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Response to bupropion in depression (
27622933
)
Cardiac troponin-I levels (
31014085
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Joint mobility (Beighton score) (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Periodontitis (Mean PAL) (
24024966
)
Interacting Genes
126 interacting genes:
A1BG
ACTA1
ADAP2
ADRB2
AKT1
AMBRA1
ANXA6
APLP1
APP
ARHGAP15
ARPP19
ARSA
BAD
BAG5
BCL2L1
BDH2
CALM1
CAV1
CDC42EP2
CDC42EP3
CDC42SE1
CDK4
CHRM5
COL25A1
CRYAB
CSNK1A1
CSNK1D
CSNK2A1
CSNK2A2
CTNND1
CTSD
CYCS
DMTN
DNAJC5
DOCK7
DYRK1A
EEF1A1
EGFR
EIF3G
ELK1
ENC1
ENSA
FBXL5
FGR
FKBP4
FYN
GABARAPL1
GAPDH
GBA
GRK1
GRK2
GRK5
GRK6
GSK3B
H1-1
H1-2
HSD17B4
HSP90AA1
HSPB2
HSPB6
HSPB8
KIAA1191
KLC1
KLK6
LYN
MAP1B
MAPK1
MAPK8IP1
MAPT
MEF2D
MT-CO1
MT-CO3
NEDD4
NEDD4L
PAK3
PARK7
PDE4DIP
PDIA2
PELP1
PFDN2
PLCB2
PLD1
PLK1
PLK2
PLK3
PPP3CA
PRDX1
PREP
PRKCE
PRKN
PTK2B
RABAC1
RNF10
SAP30BP
SDF4
SEPTIN4
SIAH2
SLC6A3
SMURF2
SNCAIP
SNCB
SPTBN1
SQSTM1
SRC
SRI
STAMBP
SYK
SYN1
TGM1
TH
TOR1A
TPPP
TUBA1A
UBB
UBC
UBE2D2
UBE2W
USP2
USP47
USP7
USP8
YOD1
YWHAB
YWHAE
YWHAH
ZRANB1
91 interacting genes:
ABRAXAS2
ACBD3
ACOX3
AIMP2
ANAPC5
ARHGAP5
ASH2L
AXIN1
BTRC
CANX
CNKSR2
CUEDC1
DAB2
DAZAP2
DGCR2
EGFR
EPHA1
FKBP4
FLNB
FUBP1
GNG2
HDGFL3
ING2
IRF3
IRF8
ITGB1BP1
KLF5
LAPTM5
LATS1
LMNA
MAVS
NEK6
NKIRAS1
NRAS
PDE4B
PPID
PRICKLE1
PRICKLE2
RAB13
RAB14
RAB17
RAB22A
RAB25
RAN
RAP1B
RASD2
RASL12
RHOA
RHOD
RLIM
RNF11
RNF111
RNF2
RNF20
RPS27A
RRAS2
RTN4IP1
RUNX2
RUNX3
SF3A2
SKIL
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SMAP1
SNCA
SNRNP70
SOCS6
SPART
SRSF4
TFPI2
TGFBR1
TMEM139
TNPO3
TOP2A
TRAF2
TRAF4
TSSK4
TXNIP
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2L3
USP15
XPO1
YY1
ZBTB44
Entrez ID
6622
64750
HPRD ID
01227
06901
Ensembl ID
ENSG00000145335
ENSG00000108854
Uniprot IDs
H6UYS5
P37840
Q96DE7
Q9HAU4
PDB IDs
1XQ8
2JN5
2KKW
2M55
2N0A
2X6M
3Q25
3Q26
3Q27
3Q28
3Q29
4BXL
4R0U
4R0W
4RIK
4RIL
4ZNN
5CRW
6A6B
6CT7
6CU7
6CU8
6FLT
6H6B
6I42
6L1T
6L1U
6L4S
6LRQ
6OSJ
6OSL
6OSM
6PEO
6PES
6RT0
6RTB
6SST
6SSX
6UFR
6XYO
6XYP
6XYQ
1ZVD
2DJY
2JQZ
2KXQ
2LTZ
6FX4
Enriched GO Terms of Interacting Partners
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