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UBR5 and CIB1
Data Source:
HPRD
(two hybrid, in vitro)
UBR5
CIB1
Description
ubiquitin protein ligase E3 component n-recognin 5
calcium and integrin binding 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Membrane
Apical Plasma Membrane
Lamellipodium
Dendrite
Growth Cone
Vesicle
Filopodium Tip
Ruffle Membrane
Sarcolemma
Neuron Projection
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Molecular Function
RNA Binding
Protein Binding
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Binding
Ubiquitin Protein Ligase Activity
Calcium Ion Binding
Protein Binding
Protein C-terminus Binding
Calcium-dependent Protein Kinase Inhibitor Activity
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Small GTPase Binding
Protein-membrane Adaptor Activity
Ion Channel Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Gene Expression
Viral Process
Positive Regulation Of Protein Import Into Nucleus
Progesterone Receptor Signaling Pathway
Protein K48-linked Ubiquitination
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Histone H2A K63-linked Ubiquitination
Regulation Of Double-strand Break Repair
Negative Regulation Of Double-strand Break Repair
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell-matrix Adhesion
Response To Ischemia
Double-strand Break Repair
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Endomitotic Cell Cycle
Cell Adhesion
Spermatid Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Neuron Projection Development
Platelet Formation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Cytoplasmic Microtubule Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Thrombopoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Division
Regulation Of Cell Division
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Protein Targeting To Membrane
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Protein Localization To Plasma Membrane
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Male Germ Cell Proliferation
Pathways
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Diseases
GWAS
Chromosomal aberration frequency (total) (
31586183
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Rate of cognitive decline in mild cognitive impairment (time interaction) (
22833209
)
Type 2 diabetes (age of onset) (
28060188
)
Interacting Genes
30 interacting genes:
BARD1
CIB1
CSPP1
DYRK2
ERG
GSK3B
KPNA1
KPNA2
KPNB1
MAPK1
MOAP1
NR1I2
OTUD5
PAIP1
PAIP2
PCK1
PGR
SATB1
SMAD2
SOX2
TCEA1
TOPBP1
TXNIP
UBC
UBE2A
UBE2B
UBE2D2
UBE2D3
UBE2L3
ZNF207
37 interacting genes:
AURKB
CALCB
CD27
CDK4
CEACAM6
EIF4G1
ELAPOR1
EXOSC10
FEZ1
FUCA1
GLIS3
IFI6
ITGA2B
LSS
NBR1
NCK2
NME4
NRIP1
ONECUT3
PAX3
PAX7
PLK2
PLK3
PRKDC
PSEN1
PSEN2
PTK2
RAC3
SCAF1
SSX7
TERT
TMEM95
TSGA10IP
UBR5
WAS
ZBTB49
ZDHHC17
Entrez ID
51366
10519
HPRD ID
06436
03800
Ensembl ID
ENSG00000104517
ENSG00000185043
Uniprot IDs
O95071
A0A140VK09
Q99828
PDB IDs
1I2T
2QHO
3PT3
1DGU
1DGV
1XO5
1Y1A
2L4H
2L4I
2LM5
6OCX
6OD0
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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