PIBF1 and TP53BP2

Data Source:
BioGRID (two hybrid)

		PIBF1	TP53BP2
Description		progesterone immunomodulatory binding factor 1	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Centrosome Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Interleukin-4 Receptor Binding Protein Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Immune System Process Mitotic Metaphase Plate Congression Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Cilium Assembly Protein Localization To Centrosome Mitotic Spindle Assembly Non-motile Cilium Assembly	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood pressure measurement (low sodium intervention) ( 24165912) Gout ( 32238385) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Waist circumference ( 28552196)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		106 interacting genes: ALAS1 AMOT AMOTL2 ANKRD23 ANKRD28 APP ARHGAP45 ARID5A C2CD6 C7orf57 CARD10 CARD9 CBX8 CCDC13 CCDC136 CCDC138 CCHCR1 CDC37 CDK18 CEP135 CEP19 CEP63 CEP70 CFAP53 CWF19L2 DAXX DISC1 DMAP1 DNAJB13 EFHC2 ENKD1 FAM161A FAM50B GMCL1 GOLGA2 GPKOW GRIPAP1 HAUS1 HOMEZ IGFN1 KANK2 KATNBL1 KIF9 KIFC3 KLHL2 LARP1B LMNB2 LZTS1 MAD1L1 MAP3K2 MCRS1 MDFI MFAP1 MORF4L1 MORF4L2 MTUS2 NEBL PHF1 PICK1 PKP2 PLEKHA7 POLDIP3 POU6F2 PPP1R18 PRPF18 PTPN21 RAB11FIP2 RBM11 RBM48 RNF151 RNF169 RSPH14 SCNM1 SLU7 SORBS3 SPATA18 STEEP1 SYT17 TAX1BP1 TCEA2 TFIP11 TNFAIP3 TNIP1 TNIP3 TP53BP2 TRAF2 TRAF5 TRIM27 TSGA10 TSHZ2 TSHZ3 UNC45A USP15 USP2 UTP14C XIAP ZBTB16 ZBTB4 ZC2HC1C ZFC3H1 ZFHX3 ZNF250 ZNF35 ZNF438 ZNF620 ZNF774	122 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC85A CCDC92 CDC5L CEP55 CEP95 CGN CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KDM1A KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NDC80 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RASSF8 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG YWHAQ ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		10464	7159
HPRD ID		06337	11803
Ensembl ID		ENSG00000083535	ENSG00000143514
Uniprot IDs		Q8WXW3	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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