PIBF1 and ARHGAP45

Data Source:
BioGRID (two hybrid)

		PIBF1	ARHGAP45
Description		progesterone immunomodulatory binding factor 1	Rho GTPase activating protein 45
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Centrosome Centriolar Satellite	Extracellular Region Cytosol Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen
	Molecular Function	Interleukin-4 Receptor Binding Protein Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Immune System Process Mitotic Metaphase Plate Congression Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Cilium Assembly Protein Localization To Centrosome Mitotic Spindle Assembly Non-motile Cilium Assembly	Intracellular Signal Transduction Neutrophil Degranulation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways			Rho GTPase cycle Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood pressure measurement (low sodium intervention) ( 24165912) Gout ( 32238385) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Waist circumference ( 28552196)
Interacting Genes		106 interacting genes: ALAS1 AMOT AMOTL2 ANKRD23 ANKRD28 APP ARHGAP45 ARID5A C2CD6 C7orf57 CARD10 CARD9 CBX8 CCDC13 CCDC136 CCDC138 CCHCR1 CDC37 CDK18 CEP135 CEP19 CEP63 CEP70 CFAP53 CWF19L2 DAXX DISC1 DMAP1 DNAJB13 EFHC2 ENKD1 FAM161A FAM50B GMCL1 GOLGA2 GPKOW GRIPAP1 HAUS1 HOMEZ IGFN1 KANK2 KATNBL1 KIF9 KIFC3 KLHL2 LARP1B LMNB2 LZTS1 MAD1L1 MAP3K2 MCRS1 MDFI MFAP1 MORF4L1 MORF4L2 MTUS2 NEBL PHF1 PICK1 PKP2 PLEKHA7 POLDIP3 POU6F2 PPP1R18 PRPF18 PTPN21 RAB11FIP2 RBM11 RBM48 RNF151 RNF169 RSPH14 SCNM1 SLU7 SORBS3 SPATA18 STEEP1 SYT17 TAX1BP1 TCEA2 TFIP11 TNFAIP3 TNIP1 TNIP3 TP53BP2 TRAF2 TRAF5 TRIM27 TSGA10 TSHZ2 TSHZ3 UNC45A USP15 USP2 UTP14C XIAP ZBTB16 ZBTB4 ZC2HC1C ZFC3H1 ZFHX3 ZNF250 ZNF35 ZNF438 ZNF620 ZNF774	9 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 TRIM50 ZUP1
Entrez ID		10464	23526
HPRD ID		06337	03097
Ensembl ID		ENSG00000083535	ENSG00000180448
Uniprot IDs		Q8WXW3	B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619
PDB IDs			3D25 3FT3
Enriched GO Terms of Interacting Partners?
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