CACNG2 and DLG3

Data Source:
HPRD (in vitro)

		CACNG2	DLG3
Description		calcium voltage-gated channel auxiliary subunit gamma 2	discs large MAGUK scaffold protein 3
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Channel Regulator Activity Ionotropic Glutamate Receptor Binding	Protein Binding Kinase Binding Phosphatase Binding
	Biological Process	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity
Pathways		Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Ergocalciferol Enflurane Spironolactone Ethanol Butamben Bioallethrin
Diseases			Non-syndromic X-linked mental retardation
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)	Mean platelet volume ( 32888494)
Interacting Genes		11 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2 WIPF1	48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		10369	1741
HPRD ID		04220	02177
Ensembl ID		ENSG00000166862	ENSG00000082458
Uniprot IDs		Q9Y698	Q59FY1 Q92796
PDB IDs		6DLZ 6DM0 6DM1 6O9G	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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