CACNG2 and GRIA1

Data Source:
HPRD (in vivo)

		CACNG2	GRIA1
Description		calcium voltage-gated channel auxiliary subunit gamma 2	glutamate ionotropic receptor AMPA type subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Early Endosome Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane Perisynaptic Space
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Channel Regulator Activity Ionotropic Glutamate Receptor Binding	Amyloid-beta Binding AMPA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Signal Transduction Chemical Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway COPII Vesicle Coating Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Depression Cellular Response To Ammonium Ion Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of NMDA Receptor Activity
Pathways		Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions	COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation
Drugs		Ergocalciferol Enflurane Spironolactone Ethanol Butamben Bioallethrin	Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)
Diseases
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)	Adult body size ( 32376654) Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 28991256 25056061 30285260 23974872) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)
Interacting Genes		11 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2 WIPF1	26 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46
Entrez ID		10369	2890
HPRD ID		04220	00695
Ensembl ID		ENSG00000166862	ENSG00000155511
Uniprot IDs		Q9Y698	P42261 Q59GL5
PDB IDs		6DLZ 6DM0 6DM1 6O9G
Enriched GO Terms of Interacting Partners?
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