CACNG2 and WIPF1

Data Source:
BioGRID (two hybrid)

		CACNG2	WIPF1
Description		calcium voltage-gated channel auxiliary subunit gamma 2	WAS/WASL interacting protein family member 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Ruffle Cytosol Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Channel Regulator Activity Ionotropic Glutamate Receptor Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity	Actin Polymerization Or Depolymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Other Organism Protein-containing Complex Assembly
Pathways		Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Ergocalciferol Enflurane Spironolactone Ethanol Butamben Bioallethrin
Diseases
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)	Atrial fibrillation ( 30061737 29892015) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		11 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2 WIPF1	26 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 NCK2 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70
Entrez ID		10369	7456
HPRD ID		04220	03835
Ensembl ID		ENSG00000166862	ENSG00000115935
Uniprot IDs		Q9Y698	A0A140VJZ9 O43516 Q2YDC4
PDB IDs		6DLZ 6DM0 6DM1 6O9G	2A41
Enriched GO Terms of Interacting Partners?
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